BOTEC Analysis, a group of global researchers, practitioners, and former policy makers who work to solve problems of public health and safety, conducted an interdisciplinary investigation into the drivers of smoking cessation in five countries with alternative nicotine delivery systems (ANDS) markets. The result of this study was a series of five national case studies for Australia, Canada, Great Britain, Japan, and South Korea that highlighted lessons and specific recommendations that may be practical for successful cessation efforts around the world.